Growth Hormone Peptides: CJC-1295, Ipamorelin & MK-677

Why not just take HGH?

Direct HGH injections shut down your body's natural production and are expensive, regulated, and prone to side effects. Growth hormone secretagogues (GHS) work differently — they stimulate your pituitary to release your own GH in natural pulses.

The major players

CJC-1295 (no DAC)

A growth hormone-releasing hormone (GHRH) analog. Half-life ~30 minutes. Typically combined with a GHRP for synergy.

CJC-1295 (with DAC)

Same molecule but with Drug Affinity Complex — extends half-life to ~8 days. One injection per week. Pros: convenience. Cons: continuous elevation rather than pulses.

Ipamorelin

A GHRP (growth hormone-releasing peptide). Selective — stimulates GH without significantly raising cortisol or prolactin. The "cleanest" GHRP.

Tesamorelin

FDA-approved for HIV-related lipodystrophy. Particularly effective at reducing visceral fat. More potent GHRH than CJC-1295.

MK-677 (Ibutamoren)

Oral, once daily. Not technically a peptide — it's a small molecule mimetic. Pros: no injections. Cons: significant water retention, increased appetite, can affect insulin sensitivity.

Classic stack

CJC-1295 (no DAC) + Ipamorelin — taken together 1-3x daily, on an empty stomach, before bed and/or post-workout. The two compounds amplify each other's effects.

What to expect

• Improved sleep (often within days)
• Better recovery from training (2-4 weeks)
• Body composition changes (8-12 weeks)
• Slightly increased appetite

Bloodwork to monitor

IGF-1 levels every 8-12 weeks. Target: upper third of the reference range. If IGF-1 goes above range, lower the dose.